Some of the factors are:
<span>-Moderate climate.
-central geography,
-ease of transportation,
-highways,
-railroads,
-location near a large body of water
</span>Large cities tend to develop far from cities that had either too hot or too cold temperature. It also must be easily accessible by other regions and provide the people with necessary resources that help them sustain their living (such as water, food crops, woods, etc)
Interleukin-5 (IL-5). IL-5 is responsible for the recruitment and maturation of eosinophil. Eosinophils on the other hand are majorly involved in the inflammatory response in asthma- characterised by narrowing of the airways. Mepolizumab and reslizumab are, therefore, anti-IL-5
That it can send signals to diffrent people
