Answer:
97%
Explanation:
PKU is caused by a recessive mutation, which means that affected individuals are homozygous and recessive (<em>tt</em>).
<u>The frequency of genotypes according to Hardy-Weinberg equilibrium is:</u>
where p is the frequency of the <em>T</em> allele and q is the frequency of the <em>t</em> allele.
Affected individuals are 1 in 4500, which means the frequency of <em>tt </em>genotype is 1/4500.
If the population is in Hardy-Weinberg equilibrium,
The sum of the allele frequencies adds up to 1, therefore:
p + q = 1
p= 1 - q
p= 1 - 0.015
p= 0.985
The frequency of the TT genotype (homozygous wild-type individuals) will be:
97% of the population will have the homozygous wild-type TT genotype.