A karyotype is the number and appearance of chromosomes in the nucleus of an eukaryotic cell. Karyotypes also describe the chromosomes count of an organism and the appearance of these chromosomes under the microscope. Cell which lack cell cycle control are often cancerous cells and they look different under the microscope compared to the normal cells. Cancerous cells will look different under the microscope in term of number of chromosomes, size, length, positioning and general appearance.
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The inheritance of gene expression patterns, in the absence of the initiating signal, is called Epigenetic regulation.
Epigenetic changes can be defined as inherited variations which are not present in the DNA sequence. Gene expression is regulated at different levels and not merely in response to DNA modifications. Examples of epigenetic control include DNA methylation, histone deacetylation and mi-RNA expression.
Epigenetic mechanisms add an adaptive layer of control in the regulation of gene expression that allows an organism to adapt to a dynamic environment.
Epigenetic regulation increases the functional intricacy of deoxyribonucleic acid (DNA) by changing chromatin structure, nuclear organization as well as transcript stability.
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