Numerous antiepileptic medications, such phenytoin, have been designed to block voltage-gated sodium channels (VGSC) in neuronal membrane. In addition, multiple toxins and pharmacological modulators work by attaching to various biophysical states of the VGSC to cause their effects. Depending on how modulatory agents act, some VGSC states are stabilized or destabilized, altering the channel's biophysical properties. The first anticonvulsant to successfully treat epileptic disorders without causing undesirable side effects such as brain drowsiness was phenytoin.
Phenytoin has been indicated to block high-frequency neuronal activity potentials from the inner vestibule of the pore, as demonstrated by electrophysiological research and site-directed mutation.
Frequency and voltage both affect phenytoin binding.
There are theories that phenytoin interferes with the late sodium current that sustains depolarizations in epilepsy by blocking non-inactivated channels.
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Explanation:
The sun provides energy to plants. The plants are eaten by herbivore/omnivores transferring the energy from the plant to the herbivore/omnivore, then the carnivore eats the herbivore/omnivore which gives the carnivore the energy
Answer:
The glomerulus is a knot of cappilaries inside the Bowman's capsule. ... Podocytes are cells that have 'foot-like extensions' which are wrapped around a capillary. This increases the surface area for filtration.
Explanation:
B. Cells reproduce independently and viruses require a host to reproduce
B. More
Because as the air warms it’s molecules move farther apart, making room for more molecules.
The last one is True
