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The growth of lymphoid tissue in the gut is fueled by TNFa. Because TNF/Rorc(gt)/ mice, who express higher amounts of TNF but lack RORgt+ LTi cells, also generate lymphoid tissue in sites of inflammation, the development of this ectopic lymphoid tissue was not contingent on the presence of conventional RORgt+ LTi cells. Surprisingly, these animals produced a number of lymph nodes that resembled those of wild type animals in both structure and function. When stromal cells were activated during the late stages of embryogenesis and when an organogenic pathway that permitted the formation of lymph nodes was activated, TNF generation by F4/80+ myeloid cells located inside the anlagen was crucial.
to know more about peripheral or secondary lymphoid organs - <u>brainly.com/question/13553292</u>
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