The central nervous system receives the excitation from a sensory neuron that has been stimulated by its nociceptors. Notably, these fibres deliver excitement to the sensory neuron's cell body, which is located in the spinal cord's dorsal root ganglia. The sensory neuron in the dorsal root ganglion transmits excitatory postsynaptic potentials (EPSPs) to motor neurons and interneurons after receiving the action potential from these fibres.

By releasing neurotransmitters into the central nervous system, the sensory neuron does this. Excited somatic motor neurons contract and depolarize the targeted muscles to complete the withdrawal reflex. The motor neuron, which leaves the spinal cord and enters the peripheral nervous system, is where this depolarization travels.

Therefore, sensory neuron to motor neuron is responsible for the sensitization of the withdrawal response.

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