Not only were the royal coffers depleted, but two decades of poor harvests, drought, cattle disease and skyrocketing bread prices had kindled unrest among peasants and the urban poor.
Answer:1-infectious Eurasian diseases
2-attempts of assimilation (and Manifest Destiny)
3-relocation attempt (Indian Removal Act of 1830)
4-diminished food supply for nomadic tribes
5-the introduction of horses and other animals to the new world (through the Columbian Exchange)
