Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
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Coyote population change due to change occur in the climate.
<h3>How coyote population changed?</h3>
The modern Northeast (Maryland) coyote population changed from the historic (North Dakota) population over the past 70 years due to climate change as well as change that occurs in their genes. Climate change is the major factor that is responsible for change in coyote population.
So we can conclude that coyote population change due to change occur in the climate.
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Answer:
Option B) functions to increase sodium reabsorption.
Explanation:
Aldosterone is an hormone secreted by the cortex of the adrenal gland. The adrenal gland is situated at the superior poles of the right and left kidneys.
Aldosterone regulates sodium homeostasis and as such helps to control blood volume and blood pressure.
Aldosterone is secreted in response to decreased blood pressure (hypotension) to increase sodium reabsorption from urine, sweat, and the gut. Also excessive aldosterone levels (too high sodium) can lead to high blood pressure (hypertension).
I would have to say conspiracy.
Answer:
oxygen, sulfur, selenium, tellurium, polonium, and ununhexium (O, S, Se, Te, Po, and Uuh, respectively)
Explanation:
i hope it helps all this are 6 valence from electron and form 2-iron.
