If you're meaning just a sentence with these two words, then:
She approached the significant hole in the wall, peering through it, a soft sigh of defeat passing her lips when she saw that the impenetrable vault she was meant to go wasn't there.
That help any?
Banquo's ghost appears in act 3, scene 4, and sits down in Macbeth's place. The fact that Banquo's ghost chooses to sit in the king's seat is significant because it foreshadows how Banquo's descendants will inherit the throne, as the witches predicted.
