This might give you the general idea
Metastasis is the process of spreading cancer where the it spreads from one organ to another area of organ in the body. The cancer cells would break away from its original growth and move to other sites to grow tumors. However, this is not only limited to cancer. It can also happen with other diseases.
Im pretty sure the answer is 2 liters per minute via nose canula. it would be 4 liters via mask.
this is starting out, anyway. as copd gets worse, the oxygen flow needs to be raised. so ultimately the flow rate depends on how much oxygen the individual's body needs in order to keep the o2 saturation level between 88 and 92.