Explanation:

Whether an added sugar contains more or less fructose versus glucose has little impact on health. (An exception may be people with diabetes who need to control their blood glucose, in which case a higher-fructose, lower-glucose sugar may be preferable
Inference is d. An observation is something you sense through taste,touch,smell, hear, and see
I would say D! Purely because it is looking at the effects of humans (therefore related to topics more geographical).
Hope that helps. :)
Amino acid differs at the glutamine, which is converted to valine in hemoglobin S. the body produced hemoglobin S due to a point mutation in the DNA sequence which results in different amino acid to be formed during translation of DNA sequence codons.