OBJECTIVES: To analyze the occurrence and types of neoplasias that have developed in patients submitted to orthotopic heart transplantation in the Cardiac Transplantation Program of the Paulista School of Medicine, Federal University of São Paulo.
METHODS: The present study presents an observational analysis of 106 patients submitted to orthotopic heart transplantation from November 1986 to September 2002, who survived for more than 30 days after the procedure. The immunosuppressive regimen consisted of triple therapy with cyclosporin A, azathioprine and corticosteroid. Only two patients received, in addition to triple therapy, the addition of orthoclone OKT-3. The mean follow-up period was 61.4 months. (variation from two months to 192 months).
RESULTS: Twenty-three patients (21.3%) developed neoplasias, of which 56.5% had skin neoplasms, 30.1% had solid tumors and 13.4% had post-transplantation lymphoproliferative disease (PTLD). The mean interval between transplantation and the diagnosis of neoplasia was: skin - 54.9 months, solid tumors - 24.8 months and DLPT - 70.3 months.
CONCLUSIONS: The occurrence of malignant neoplasms was relatively common in the analyzed population. Skin cancer prevailed in relation to other neoplasms and solid tumors were more diagnosed than lymphoproliferative diseases in this series of patients.
I like to go to SLEEP when I get home from a long day.
I SLEEP when I'm bored or tired.
I have to SAY you are very nice.
I know how to SAY blue in Spanish.
I will HAVE to finish it tomorrow.
I HAVE five dollars.
I will PUT a toy car on my Christmas list.
I can PUT my legs over my head.
I can BRING you some snacks.
I will BRING you your phone.
I GO to school.
I GO to fun places with my friends.
I can DO anything.
I can DO a cartwheel.
I want you to COME to my party.
I will COME to your house.
I DREAM about monsters.
I DREAM sometimes about good memories.
I LOOK LIKE my mom.
I also LOOK LIKE my dad.
(I put the words in big letters so you get mixed up)
