The answer is a) human rights issues
Upside and downside can mean a positive and a negative aspect of something, respectively. However, none of the options here present a couple of something negative and something positive: so I think we need to use the local meaning. So our analogy is:
on one extreme of some location (on the upper side): on the other extreme.
Therefore the best other couple is outside and inside: they also show two opposite locations.
Answer:
Pear
Explanation:
A pear will ripen the fastest/quickest, In a case if you are keeping it in a chill like container for a long period of time, A pear will ripe faster the longer you keep it in a cold/chill time duration