First, governments in most countries have created laws against monopolies for large corporations, which prevents that corporations have influence or power to weaken or do away with the smaller companies that are forming and gaining power and profitability. Second, large corporations use this as a way to gain competitiveness and revitalize the market, since it is known that where competition does not exist, it falls into mediocrity. Thus, a market where there are several companies that compete, keep alive the economic system, and there is always the possibility for large corporations, to buy the rival company, and gain with all their human capital, ideas, brands and fame of the company. Something like this was seen when Facebook buys WhatsApp for 21.8 billion dollars.
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1) Population curb: After the Europeans became extremely strong, they forced Indians off their homeland and placed them in reservations and such.
2)Disease: Disease brought by Europeans (i.e. measels, chicken pox, etc)
These impacted the American Indians more than weapons and technology of the days
3) Technology: Technology would be the next. As many Indians gathered and hunt (yes some did farm, not a lot, and with primitive tools), there tool weren't as enhanced as the Europeans (for example, they use wooden plows against the European iron plows. Or they still use wooden spears with hardened points or bows made of wood and arrows with stone points. On the other hand, the Europeans used muskets (IDR if they invented rapid-fire yet or not) body armor (knight's armor type, kinda like conquistadors) and cannons, etc. Technology helped Europeans both gain allies and defeat their enemies relatively easy.
4) Allies and Enemies: As Europeans allied themselves with certain tribes, the other tribes would feel unsafe and the sort, and would make war. This led too numerous wars, and the fall of many Indian tribes (and European powers. Take for example, the French and Indian war).
5) Crops: Europeans introduced many different crops that were later part of Indian food life and the sort. These include wheat, barley, rice, turnips, etc. Some of these crops impacted Indian life, and became one of the many foods they eat.
hope this helps