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ivanzaharov [21]
3 years ago
9

How enzymes inhibitions studies in the formulation and development of drugs​

Biology
1 answer:
lesya [120]3 years ago
7 0

Answer:

Enzyme inhibitors may alter the elimination rate of a particular drug or inhibit detoxication pathways

Explanation:

An enzyme inhibitor is a chemical compound capable of binding to an enzyme in order to reduce its activity. An enzyme inhibitor may bind to an active site and thus decreases the rate of reaction (direct inhibition). Enzyme inhibitors may act 1-to Inhibit detoxification enzymes and 2-reduce the elimination rate of enzyme drugs, thereby having dose-dependent toxicity effects. For example, many medicines are based on the inhibition of Cytochromes P450 (CYPs) proteins, which are a superfamily of enzymes required for drug metabolism.

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There are 100 cats in a population that follows hardy-weinberg conditions. 4 cats display a recessive white coat color. how many
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We know that Hardy-Weinberg conditions include the following equations:


p^{2}+2pq+ q^{2}=1


where p+q=1


And where p = dominant, and q = recessive; this means that p^{2} is equal to the homozygous dominant, 2pq is the heterozygous, and q^{2} is the homozygous recessive .


So we have 100 total cats, with 4 having the recessive white coat color. That means we have a ratio of \frac{4}{100} or 0.04. Let that equal our q^{2} value.


So when we solve for q, we get:


q^{2}=0.04

q=\sqrt{0.04} =0.2


Now that we have our q value, we can use the other equation to find p:


p+q=1


p+0.2=1


p=0.8


So then we can solve for our heterozygous population:


2pq=2(0.8)(0.2)=0.32


This is the ratio of the population. So we then multiply this number by 100 to get the number of cats that are heterozygous:


0.32*100=32cats


So now we know that there are 32 heterozygous cats in the population.

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Answer:

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