It doesn't have a definition it's a phrase president Thomas Jefferson used in his first inaugural address in 1801 calling for a cautious, isolationist foreign policy
I'm not sure what you mean by "historically", but there are many key features of London:
Big Ben
Buckingham Palace
the Thames River
London Bridge
London Eye
Trafalgar Square
Hyde Park
Westminster Abbey
the Globe Theater
Answer:
Africa
Explanation:
The continent of _____ was active in trade across the Mediterranean and Bharat Ocean XD
It would be "Polynesia" that was a region of Oceania greatly affected by European colonization, forced slavery, and deadly diseases, since this territory was highly advantageous for countries looking to increase production and expand their empires.