When a DNA sequence alteration results in a stop codon rather than a codon that specifies an amino acid, it is known as a nonsense mutation. This is rarely seen in 10% of patients with genetic disease.
<h3>What is nonsense mutation?</h3>
A nonsense mutation in a DNA sequence causes a premature stop codon, also known as a nonsense codon, in the transcribed mRNA as well as a shortened, ineffective, and typically nonfunctional protein product.
Because stop codons, also known as nonsense codons, signal the completion of protein synthesis rather than encoding for an amino acid, they are the source of the term "nonsense mutation."
Examples of illnesses for which nonsense mutations have been implicated as contributing factors include: Cystic fibrosis (produced by the G542X mutation in the cystic fibrosis transmembrane conductance regulator); (CFTR) Beta-globin (thalassemia) Hurler disease.
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Most becomes carbon dioxide and the rest of it often becomes fossil fuels such as coal
The oncogenesis process is caused by these mutations in the genetic material of normal cells, which alter the normal balance between proliferation and cell death. As a result there is an uncontrolled cell division and an evolutionary process of these cells through natural selection within the organism. Rapid and uncontrolled reproduction of cells can produce benign tumors and some types of these tumors can become malignant, which is what is known as cancer. Benign tumors do not spread to distant parts of the body or invade other tissues, and usually do not pose a threat to life unless they compress vital structures or have some physiological activity (for example, that they are capable of producing a hormone) . Malignant tumors are able to invade other organs, spread to distant places (a process known as metastasis) and become a threat to life.
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