Great Britain, Spain, and New Zealand
Answer:
2 & 3
Explanation:
not 4 sure if there's more though
The drug that should be routinely evaluated for possible toxicity is digoxin.
<h3>What is toxicity?</h3>
The term toxicity refers to the point that a drug could lead to harm in a patient. This often stems from the use of the drug.
Given that the drug digoxin has been traditionally used to treat heart conditions an could lead to toxicity, it ought to be evaluated for possible toxicity.
Learn more about toxicity:brainly.com/question/19603594
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Answer:
The muscle's insertion
Explanation:
The moveable end of the muscle that attaches to the bone being pulled is called the muscle's insertion, and the end of the muscle attaches to a fixed (stabilized) bone is called the origin.
Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
