Cancer, brain damage, some sort of disease,
<span>English colonists were greedy liars who thought themselves better than Native Americans based on their idea of civility. English colonists thought English was a better way to communicate and considered Native American language as the language of the savages. The Native Americans were a peaceful welcoming people, who tried to help the colonists but their help was taken advantage of causing them to grieve the day they ever allowed the colonist to land on Native American land. So Native Americans grieved the day they every met the colonists and helped the colonists.</span>
I believe the answer is: Formal region
Each formal region would be differentiated by their own unique government structure that separate each region with the other. Each border on the sides of each region would consist of some sort of boundaries ( could be natural or human made) that accepted by all regions as a legal separation between their jurisdiction.