Answer:
A crime scene sketch depicts the overall layout of a location and the relationship of evidentiary items to the surroundings. It can show the path a suspect or victim took and the distances involved. It can be used when questioning suspects and witnesses.
Explanation:
I think it is A and D (at least those are the ones that made the most sence to me).
Prader–Willi syndrome (PWS) is a hereditary disorder because of loss of function of specific genes. Starting in childhood the individual converts continually hungry which often goes to obesity and type 2 diabetes. So the region of the brain would be best target is the hypothalamus. The hormones from the hypothalamus oversee physiologic purposes such as temperature, dehydration, starvation, sleep, attitude, and the discharge of other hormones within the body.
Answer:
The answer is reciprocal chromosomal translocation
Explanation:
The Philadelphia chromosome (Ph) is the truncated chromosome 22 generated by the reciprocal translocation t(9;22)(q34;q11) and was first identified in 1960 in a patient with CML [3]. Translocation of the proto-oncogene tyrosine-protein kinase (ABL1) gene located on chromosome 9 to the breakpoint cluster region (BCR) gene located on chromosome 22 results in a BCR-ABL1 fusion gene on the Ph [4, 5]. Three BCR-ABL1 fusion gene hybrids encode BCR-ABL1 protein isoforms p210, p190, and p230, which have persistently enhanced tyrosine kinase (TK) activity. These aberrantly activated kinases disturb downstream signaling pathways, causing enhanced proliferation, differentiation arrest, and resistance to cell death [6, 7]. Tyrosine kinase inhibitors (TKIs) targeting the BCR-ABL1 protein are the most successful targeted therapy for Ph-positive leukemia.
