The word "always" implied that the states should obey the federal government under any circumstances.
Most of the times, yes. I think it is important for the states to obey the federal government in order to maintain law and order in the country.
But, there's a chance that the federal government might impose a legislations that's violates the constitutions or human rights. At that point, the states need to be able to raise as the opposition from the central government.
That would make me feel mad because slavery is not good anywhere that is why it ended December 6, 1865 because people were not getting treated right they would get slapped, or woman would get taken away from their husband to be raped or be married to a white man.