Answer:
physical change probably, I would think more than chamical
The situation will be definitely different if our founding fathers only slightly patched and amended the articles of confederation and never replaced it with the United States constitution. People will not have that rights which they the Constitution of United States gives them.
There will be no systematic way to run the country, no sequence of rules and regulation. The growth will totally differ from which is in present time. The country will be in debt and no social justice will be spread.
Federal Government > State Government
The rationale for this is that we live in a global world and need collective responses to global challenges. Instead of there being a Utah response and a Virginia response to the need for more STEM graduates, there should be a US response. Economies of scale also come into play. It can cost less and be more efficient to have resources centralized.
State Government > Federal Government
America was founded after a revolution rejected a strong central monarchy and America needs to continue to honor that by allowing citizens in Utah to have different approaches than Virginia. When convenient, the states can choose to collectively band together on issues like defense but that should be the exception and not the rule.