Question

g A rare genetic disease arises from mutations in subunits of TAP (TAP1 or TAP2). Individuals with this disease are susceptible to recurrent infections. What effects would you expect from this mutation

Answer 1

Explanation:

A rare genetic diseasearises from mutations in subunits of TAP (TAP 1 or TAP 2). The individuals with this disease are susceptable to recurrent infections.

The efforts could be expected from this mutation- MHC class II molecules will not be loaded with peptides, so CD8+ T cells cannot be activated. MHC class I molecules will not be loaded with peptides, so CD4+T cells cannot be activated MHC class I molecules will not be loaded with peptides, so CD8+T cells without be activated.