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Stella [2.4K]
3 years ago
8

What is the effect of Dideoxycytidine on the replication of viral DNA.

Biology
1 answer:
MariettaO [177]3 years ago
4 0

Answer:

Several 2',3'-dideoxy-3'-thiapyrimidine nucleosides were studied for their ability to inhibit hepatitis B virus (HBV) DNA replication in a HBV-transfected cell line (2.2.15). 2',3'-Dideoxy-3'-thiacytidine (SddC) and 5-fluoro-2',3'-dideoxy-3'-thiacytidine(5-FSddC) were found to be the most potent anti-HBV compounds of those examined. Both compounds resulted in nearly complete cessation of viral DNA replication at 0.5 microM, as monitored by the absence of both intracellular episomal and secreted viral DNAs. The HBV-specific RNAs were not reduced at concentrations that completely blocked HBV DNA replication, suggesting that the inhibitory target is HBV DNA synthesis. The antiviral action of SddC and 5-FSddC was reversible. The concentration of SddC and 5-FSddC required to inhibit 50% of 4-day cell growth in culture was 37 microM and more than 200 microM, respectively. Unlike 2',3'-dideoxycytidine, these two compounds do not affect mitochondrial DNA synthesis in cells at concentrations lower than that required to inhibit cell growth. In view of the potent and selective antiviral activity, both SddC and 5-FSddC should be further evaluated for the treatment of human HBV infection.

Explanation:

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An example of an atom that has no charge is one that has
Mekhanik [1.2K]

Answer:

2 protons, 2 electrons, and 1 neutron.

Explanation:

Atoms are made-up of sub particles called protons and neutrons found in the nucleus. The protons are positively charge while the neutrons have no charge. The electrons are found in the shell orbitals and are negatively charged and in constant motion. 2 protons will neutralize the negative charge of the 2 electrons in the outer shell.

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4 years ago
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Rina8888 [55]

Answer:

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Explanation:

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3 years ago
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Ne4ueva [31]
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8 0
4 years ago
Which equation describes the interaction between phenotype, genotype, and the environment?
bagirrra123 [75]

option B:is correct answer

may be this helpful!

3 0
3 years ago
At a deep sea whale fall, the Atlantic hagfish, the crustaceans, and the sand make up which of the following?
Zielflug [23.3K]

Answer:

I would say part of an ecosystem and community.

Explanation:

An ecosystem is a biological community of interacting organisms and their physical environment .In the bottom of the sea,there are already many animals living here and when the whale fall appears at the bottom of the ocean it becomes apart of the ecosystem as it provides them with food.

This is because when a whale dies, its body often falls to the seafloor. The whale's body then becomes food and shelter for organisms in the deep sea. This is called a whale fall. A deep-sea whale  fall might support 200 different species for as long as 10 years! Larger species, such as Atlantic hagfish, are the first to arrive to feed  on the whale flesh. Later, smaller species of snails and crustaceans come to eat the remaining flesh. Worms burrow into the sand beneath  the whale body, and bacteria feed on the whale bones.

3 0
3 years ago
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