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Stella [2.4K]
2 years ago
8

What is the effect of Dideoxycytidine on the replication of viral DNA.

Biology
1 answer:
MariettaO [177]2 years ago
4 0

Answer:

Several 2',3'-dideoxy-3'-thiapyrimidine nucleosides were studied for their ability to inhibit hepatitis B virus (HBV) DNA replication in a HBV-transfected cell line (2.2.15). 2',3'-Dideoxy-3'-thiacytidine (SddC) and 5-fluoro-2',3'-dideoxy-3'-thiacytidine(5-FSddC) were found to be the most potent anti-HBV compounds of those examined. Both compounds resulted in nearly complete cessation of viral DNA replication at 0.5 microM, as monitored by the absence of both intracellular episomal and secreted viral DNAs. The HBV-specific RNAs were not reduced at concentrations that completely blocked HBV DNA replication, suggesting that the inhibitory target is HBV DNA synthesis. The antiviral action of SddC and 5-FSddC was reversible. The concentration of SddC and 5-FSddC required to inhibit 50% of 4-day cell growth in culture was 37 microM and more than 200 microM, respectively. Unlike 2',3'-dideoxycytidine, these two compounds do not affect mitochondrial DNA synthesis in cells at concentrations lower than that required to inhibit cell growth. In view of the potent and selective antiviral activity, both SddC and 5-FSddC should be further evaluated for the treatment of human HBV infection.

Explanation:

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A) It's a form of work.

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A Venus flytrap produces new leaves from the step tip.
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All instructions for proteins, like hemoglobin, are stored in our _______, which is located in a cell’s ______________. This DNA
svlad2 [7]

Answer:

1. DNA

2. Nucleus

3. mRNA

4. Transcription

5. Nucleus

6. mRNA

7. Cytoplasm

8. Ribosome

9. Translation

10. anti-codons

11. codon

12. amino acids

13. protein

Explanation:

Deoxyribonucleic acid or DNA hold all the instructions that make up an organism. It determines the physical structure and even the function of the different cells that make up all organisms.

The DNA are all stored in the NUCLEUS of cells. Typically, eukaryotic cells have a nucleus except red blood cells. The nucleus has a nuclear envelope that keeps the DNA stored inside but it has nuclear pores that allows it to interact with the cytoplasm.

In order for DNA to be replicated, it needs to be turned into messenger RNA, otherwise known as mRNA. The mRNA decodes the DNA in order for the cell to use the code. The process is called transcription.

Transcription is done within the nucleus. Before the cell can understand what to do with DNA, mRNA transcribes to know what information it needs to produce specidic proteins.

Once transcription is done, it will then bring the information out of the nucleus and into the cytoplasm. The cytoplasm is the viscous gel-like solution that holds the organelles of the cell. In the cytoplasm you have ribsomes.

Ribosomes is where protein synthesis takes place, this is why it is called the protein factory of the cell. It is a molecule that is made up of ribosomal RNA, which direct the chemical processes involved in protein synthesis. For protein synthesis to happen, it will need another type of RNA, which is the tRNA.

tRNA is transfer RNA and they translate the mRNA sequence into proteins. tRNA have amino acids attached to it.

Each 3 bases of the mRNA are collectively known as codons. These codons correspond with specific  tRNA that hold the anticodons. These anticodons code for specific amino acids that they also hold.

When they pair up, the tRNA drop off the amino acid which form a chain with the other tRNA amino acids that complete the code. These chain of monomers then make the protein specific to the DNA code that was copied in the beginning.

3 0
3 years ago
Glucose is present in blood plasma at a concentration of approximately 80 mg/dL. A typical 70 kg human has approximately 5 L blo
tester [92]

Answer: 48.93 mL of sprite

Volume of blood in 7 Kg human = 5 L

Percentage of plasma in blood = 55%

Volume of plasma in 5 L blood =  (1 L = 10 dL)

Concentration of glucose in plasma = 80 mg/dL

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Let the volume of sprite with 2200 mg glucose be x

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Explanation:

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Muscles do not fossilize.
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