The most serious problem faced by settlers in Virginia when they first arrived was a lack of food, since the land was difficult to farm and the Natives could be hostile. Although they soon grew enough tobacco to be able to trade efficiently.
Those in the South particularly Georgia favored it. Why not? They got terrific land. The Cherokee resisted as did the Northeastern (New England) states.
Missionaries also opposed it, but Andrew Jackson was convinced that he was performing a necessary good deed in passing it in 1830 after a long and heated debate in congress.
It was not a happy event. Tens of Thousands suffered going on the Trail of Tears.
The answer is thanksgiving.