The Party and its beliefs were placed in the period wherein Stalin rise to power and in the Stalinism's Institution in the Republics of Union of Soviet Socialist.
All the illnesses that are being passed done generations. Like cancer from all the chemicals and radiation. Or the PTSD that is passed down with the generations. There are a lot of illnesses that can be talked about.
Machines made it easier to complete hard tasks(such as the cotton gin) and they also could get work done faster than humans, which lead to a much grander scale of production in goods. Hope this helps :D