Answer:
The Various Kinases that is activated after the breaks in DNA is after the activation of ATM serine threonine kinase which helps in phosphorylation of other DNA replication check proteins, p53 protein (tumor suppressor protein) etc.
Explanation:
ATM activated by MRN complex at the site of DNA double stranded breaks by phosphorylation. MRN complex activity on ATM induces a conformational change in ATM kinase. So it can bind to its various substrate molecules that helps in DNA replication cycle arrest.
ATM phosphorylates CHK2 protein a product of CHEK2 gene, also known as effector kinases that phosphorylates and helps in deactivation of cyclin dependent kinases (CDKs) that helps in the prevention of progression of mitotic phase.
ATM also phosphorylates the inhibitors of p53 proteins which leads to the overexpression of p21, an inhibitor of (CDKs).
Answer:
You should wash your cut before and after swimming so that bacteria in the water can't infect the wound.
Let me know if its right <3
The flight from Arizona to Germany is 11 hours and 38 minutes
<span>Throughout the book Lily is going through a major spiritual transformation (just like the actual author). This causes her to begin with anger and hostility and to grow into a more understanding and forgiving person. Lily runs away from her bigoted home and is forced to make this spiritual transformation, which she does.</span>
