Question

g It has been proposed that integrin proteins undergo conformational changes when they bind to small molecules diffusing into the extracellular matrix. Because integrins are transmembrane proteins, a change in their conformation can be transmitted across the membrane to the portion of the protein that interacts with intracellular structures. What biological role does this allow integrins to play in a cell's function within a multicellular organism

Answer 1

Answer:

Cell-cell communication

Explanation:

Integrins are heterodimeric transmembrane receptors that facilitate the adhesion to the cell-extracellular matrix by attaching the cytoskeleton to this matrix. Moreover, integrins also help the cells bind with other cells. Integrins are responsible for the communication between cells and thus control tissue structure. These receptors are responsible for the attachment of fibroblasts to collagen, as well as the attachment of fibroblasts to fibronectin. It is also important to highlight that the binding of integrins with their corresponding ligands activates signaling pathways that control diverse cellular processes including, among others, cell growth, cell development, cell migration, phagocytosis, etc.