Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
Answer: health information management; information technology
Explanation:
<em>With the increase in electronic health records, more professionals are working in </em><em><u>Health Information Management</u></em><em>, which requires a familiarity with the healthcare system, as well as </em><em><u>Information technology.</u></em>
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The field of Health Information Management has seen a massive boost in recent years as more people train in this field which is necessary to input, analyze and protect the electronic health records of people.
Doing this job requires one to be well versed in both healthcare systems so that they have a familiarity with the data they are to manage, as well as information technology so that they can manage the electronic data.
Answer:
i dont think you gave us the choices but epidemiology is the study of health distribution. it determines diseases as well as shapes decisions. essentially they deal with medicine having to do with big diseases and new diseases like cancer.
B and C are both reasonable answers
In medicine, set-point refers to a weight that is difficult for your body to change. Thus, the correct option for this question is B.
<h3>What do you mean by Setpoint?</h3>
A set point may be characterized as the level or point at which a variable physiological state such as body temperature or weight significantly tends to stabilize.
It is a homeostatic mechanism that remarkably maintains numerous kinds of a variable (such as body temperature, body weight, blood glucose level, or hormone levels) within specific limits.
Therefore, in medicine, set-point refers to a weight that is difficult for your body to change. Thus, the correct option for this question is B.
To learn more about Setpoints, refer to the link:
brainly.com/question/29780871
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