The reduced potential causes hundreds of <u>voltage-gated sodium</u> channels to open on that part of the cell membrane. The depolarization of the cell causes more of <u>voltage-gated sodium </u>channels to open in adjacent parts of the cell membrane. This begins the wave of of <u>depolarization</u> moving down the axon. Depolarization begins at the <u>axon hillock.</u>
Explanation:
When there is no neuron signaling it becomes polarized, termed as resting membrane potential (RMP) at a threshold voltage (around -55 mV), due to the action of the sodium-potassium pump and the potassium leak channels.
When a change in the RMP occurs, depolarization takes place which causes the voltage-gated sodium channels to open and sodium ions rush into the nerve cell which in turn will increase the voltage threshold to nearly around +40 mV and also charges the neuron positive. This depolarization moves down the axon. This increase in threshold stops the sodium influx and opens the potassium channels to rush the potassium out of the cell.
All these actions decrease the membrane potential leading to a wave of depolarization and going back to resting state. Depolarization begins depending upon the potential gradient at the axon hillock.
<span>Gene Expression is the progression wherein the
information from a gene is used in the combination of a functional gene
product. In eukaryotic cells, genes are delimited by repressors as well as by transcriptional
activators. The repressors will muddle to the specific DNA sequences and will constrain
transcription.</span>
A mechanism that is effective in maintaining a normal glomerular blood pressure only if the systemic mean arterial pressure remains between 80 and 180 mm hg is called renal autoregulation.
<h3>What is renal autoregulation?</h3>
- Autoregulation is the inner characteristic of blood vessels present in end organs, like heart, kidney, and mind, by which they dilate or constrict in response to pressure changes, thus help to keep the blood flow generally steady.
- Usually our body tries to regulate our blood pressure in range of 50 to 150 mm Hg.
- Regulation of renal blood flow and glomerular blood pressure in kidneys is called renal autoregulation.
- There are 3 mechanisms of renal blood flow namely myogenic response (MR), tubuloglomerular feedback (TGF) and third mechanism that is independent of TGF but slower than MR.
Learn more about renal autoregulation here:
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