Answer:
The three methods are: 1) Using H-Ras- SREBP- 2 Fusion proteins, the NH2 segment can be released by two sequentia
Explanation:
Sterol regulatory element binding proteins (SREBPs) are transcription factors attached to the endoplasmic reticulum. The NH2-segment, which activates transcription, is connected to membranes by a hairpin anchor formed by two transmembrane sequences and a short lumenal loop. Using H-Ras–SREBP-2 fusion proteins, we show that the NH2-segment is released from membranes by two sequential cleavages. The first, regulated by sterols, occurs in the lumenal loop. The second, not regulated by sterols, occurs within the first transmembrane domain. The liberated NH2-segment enters the nucleus and activates genes controlling cholesterol synthesis and uptake. Certain mutant Chinese hamster ovary cells are auxotrophic for cholesterol because they fail to carry out the second cleavage; the NH2-segment remains membrane-bound and transcription is not activated.
Answer:
When portable transport ventilator alarms are ringing, the priority nursing assessment includes to check if, all the tubes of ventilators are connected properly or not because sometimes movement of the patient can disconnect the tubes.
Sometimes, obstruction of the Endotracheal tube (ETT) from mucus plugs or from patients biting on the tube, causes ringing of alarm and should be assessed on a priority basis.
Answer:
Symptoms
Decreased urine output, although occasionally urine output remains normal.
Fluid retention, causing swelling in your legs, ankles or feet.
Shortness of breath.
Fatigue.
Confusion.
Nausea.
Weakness.
Irregular heartbeat.