Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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Answer: C
Explanation: I took the test hoped this helped :)
Answer:
Broad-spectrum antibiotics can cause antibiotic resistance.
Explanation:
- Antibiotics are the substances that inhibit the growth of or kill the bacteria and hence, these are used as medications for the treatment of a lot of bacterial diseases.
- These antibiotics can either be of broad-spectrum or the narrow spectrum.
- The broad-spectrum antibiotics are the ones that are effective against a variety of bacteria, both gram-positive and negative whereas the narrow-spectrum antibiotics are the ones that target only a specific type of bacteria.
- Since the bacteria can mutate very fast and hence, develop antibiotic resistance, the doctors usually avoid prescribing broad-spectrum antibiotics and only use them when the causal bacteria is completely unknown.
- Hence, in the given case the provider prescribes separate medications for both types of bacteria.
<span> All the millions of different proteins in living things are formed by the bonding of only </span>20 amino acids<span> to make up long polymer chains.</span>
