Yes. The preamble of the Declaration of Independence states the reasons for the colonists to seek independence, as well as the legitimate reasons to overthrow a future government. The text states that this is a legitimate action when the government fails to protect the rights of the people or ensure their participation. Moreover, when a government becomes abusive and tyrannical, the people have the duty to overthrow it.
For one, the Allies had an EXTREMELY massive amount of production, which the German's desperately lacked around the end of Operation Barbarossa in the East.
Also, relating to production, the German's air force (The Luftwaffe) and Naval forces were essentially non-existent by the time the Americans landed in Sicily, but the Allies had a surplus of air assets (specifically bombers and Airborne infantry) which solidified an Allied victory in Europe.
The caning of Charles Sumner highlighted sectional tensions between the North and the South.