The witches interaction creates an eerie and unsettling mood. While predicting Macbeth's future on becoming king, they tell him that to be King he'd have to kill King Duncan. This is what creates a mood foreshadowing that something bad is going to happen.
The "for sure," I would say.
Answer:
The reader predicts that "always" will end, as will Issac and Monica's relationship.
Explanation:
Just take my word for it I've read this book at least 7 times.