Hot spots, Divergent plate boundaries and Convergent plate boundaries
Answer:
<u>1. type IV hypersensitivity: delayed-type hypersensitivity. </u>
<u>2. type I hypersensitivity: IgE </u>
<u>3. type II hypersensitivity: IgG </u>
<u>4. type III hypersensitivity: immune complexes </u>
Explanation:
Type IV hypersensitivity is cell mediated hypersensitivity rather than antibodies as in all other types of hypersensitivities. It is also known as delayed type hypersensitivity because it usually respond in 2-3 days via T-Lymphocytes rather than antibodies like IgE or IgG. So we can say that in option 5 is mismatched as it relates type IV to IgG antibodies.
Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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Answer:
see if the strips repel each other when brought close together
Explanation:
Electric fields can exert forces on objects, even if the objects involved are not touching. One way to demonstrate that electric fields exist around charged objects is to observe the effects of their forces at a distance.
Since Ike knows that each strip of tape carries a negative charge, he could see if the strips repel each other when brought close together.
Hypothalamus is a part of the brain that links the nervous system to the endocrine system via the pituitary gland. It helps maintain the internal environment constant by regulating major processes in the body such as the heart rate and the body temperature. It is therefore, both a neural and endocrine organ.
