During 1811 Amedeo Avogadro ‘s hypothesis that at the same pressure and temperature equal volumes of all gases carries equalnumbers of molecules. It also distinguished that the accurate interpretation in the reaction of hydrogen with oxygen to create water, he explained the reaction showing what happens on an atomic and molecular scale using the theory of Dalton.
I'm gonna guess you said manchuria, or China, or Russia.
In which case, Japan invades China in 1937. Starting the Second Sino-Japanese War.
The closest city that is east of the Tigris River and south of 40°N latitude is Nineveh.