Clark case summary for gizmo
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DNA replication proceeds in one direction around the bacterial chromosome.
Explanation:
Replication of DNA is preserved across most of life. Therefore, even bacteria DNA replication occurs bidirectionally. During replication of DNA, A primer is required in the initiation complex before DNA polymersae can begin replication. This is because this enzyme works by adding DNA nucleotides at the 3’ end of an existing strand. DNA can have several replication forks on one double strand in which replication occurs. For every fork, there is a leading strand whereby the replication process by DNA polymerase is continuous and the lagging strand whereby the replication is done in bits by the same polymerase enzymes. The lagging strand will, therefore, require many primers. This is becaue strands of DNA are antiparallel yet the DNA polymerase has to move in one direction. Since replication can only occur in the 5’⇒3’ direction, the antiparallel strand will be done in 5’⇒3’ chunks that will later be joined into one strand.
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