Can we have the picture please.
:)
The answer is D! I hope that helps
Answer:
The answer should be A. applied research scientist.
Explanation:
Answer:
by designing a drug with steric effects on BCR-ABL1
Explanation:
Chronic myeloid leukemia (CML) is a type of cancer that affects the bone marrow and blood cells. CML is characterized by the formation of the Philadelphia chromosome, a product of a reciprocal translocation between chromosomes 9 and 22. As a consequence of this translocation, an oncoprotein tyrosine kinase called BCR-ABL1 is formed. This protein (BCR-ABL1) is responsible for 95% of all CMLs. In this case, it is possible to inhibit BCR-ABL1 (and thus inhibit CML cell proliferation) by using a kinase inhibitor. Kinase inhibitors are drugs that inhibit kinase function by preferentially binding to the inactive conformation of the target enzyme. These proteins are used to treat cancer by blocking a functional site on the kinase, thereby inhibiting its function. Moreover, it is known that steric effects alter the mode and rate by which a drug interacts with a given target. In this case, a small molecule with steric effects on BCR-ABL1, i.e., capable of altering the shape (conformation) and reactivity of BCR-ABL1, might also be used to selectively inhibit BCR-ABL1.
It is because Madagascar has a huge biodiversity that is found only there. The biodiversity of Madagascar shows characteristics that confirm the fact the island has been isolated for about 88 million years. Specific and endemic plants and animals on the island evolved in relative isolation (plants and animals found nowhere else on Earth).
Madagascar is endangered by human activity such as deforestation, habitat destruction and hunting.
