Well, you know, I’m not exactly an expert on this topic, but I’m going to try my best to provide some sort of reasoning as to why this could be...
1. Sexting releases more hormones, and causes you too not really think about anything else and focus on... well, sexting.
2. If you don’t get an adequate response from your sexting partner(s) it could cause some sort of mental health issues, like depression. This alone would probably decrease your intellectuality, but if got worse you could start not feeding yourself properly, so your body won’t get enough nutrients, and your brain won’t function as good.
(That one might be kind of a long shot, but it’s what I’ve got.)
All in all, I’ve never sexted anyone, but I think it does decrease your intellectuality. I’m not exactly sure if this is what you meant but I hope I was able to help even a little bit.
The paralysis Charlotte is going through is an indication that the stroke affected the left side of the motor cortex
Alzheimer's disease is potentially connected to the degeneration of ACh- producing neurons
About epigenetics we can take into account certain experiences that she went through in her past and due to this some epigenetic markers that would normally protect against Alzheimer's were no longer active.
Regarding plasticity we can say that it is a consequence of her age, given that the brain no longer has the capacity to produce neurons or rearrange itself in order to make up for the damage that the stroke caused.