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kodGreya [7K]
3 years ago
6

The specificity of trypsin is determined by _________ on the enzyme. The specificity of elastase is determined by _________ on t

he enzyme. Three amino acids: Asp, His and Ser, of ________ form a triad to cleave peptide bonds of a substrate.
Biology
1 answer:
Brut [27]3 years ago
7 0

Answer:

Another Asp in something like a deep pocket; a superficial amino acid binding pocket with either a slight neutral side, neither elastase nor trypsin.  

Explanation:

  • Almost all trypsin as well as elastase contain catalytic triads. In trypsin, aspartate is the essential amino acid throughout the bag. The latter's pocket also becomes unique to charged particles (+) side-chain creatures.  
  • Elastase seems to have a pocket which really combines multiple valine residues, making it extremely difficult to reach the pocket with large bulky main chain, this therefore prefers short side chains.

The homologs with chymotrypsin include trypsin but mostly elastase. As either a central amino acid, chymotrypsin encompasses serine.

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PUNTOS POSIB!
Sindrei [870]

Aim

When dividing the world into zoogeographical regions, Alfred Russel Wallace stipulated a set of criteria by which regions should be determined, foremost the use of generic rather than species distributions. Yet, recent updates of Wallace's scheme have not followed his reasoning, probably explaining in part the discrepancies found. Using a recently developed quantitative method, we evaluated the world's zoogeographical regions following his criteria as closely as possible.

Location

Global.

Methods

We subjected presence–absence data from range maps of birds, mammals and amphibians to an innovative clustering algorithm, affinity propagation. We used genera as our taxonomic rank, although species and familial ranks were also assessed, to evaluate how divergence from Wallace's criteria influences the results. We also accepted Wallace's argument that bats and migratory birds should be excluded (although he was contradictory about the birds) and devised a procedure to determine the optimal number of regions to eliminate subjectivity in delimiting the number of regions.

Results

Regions attained using genera (eight for mammals and birds and six for amphibians) strongly coincided with the regions proposed by Wallace. The regions for amphibians were nearly identical to Wallace's scheme, whereas we obtained two new ‘regions’ for mammals and two for birds that largely coincide with Wallace's subregions. As argued by Wallace, there are strong reasons not to consider these as being equivalent to the six main regions. Species distributions generated many small regions related to contemporary climate and vegetation patterns, whereas at the familial rank regions were very broad. The differences between our generic maps and Wallace's all involve areas which he identified as being uncertain in his regionalization.

Main conclusions

Despite more than 135 years of additional knowledge of distributions, the shuffling of generic concepts, and the development of computers and complex analytical techniques, Wallace's zoogeographical regions appear to be no less valid than they were when he proposed them. Recent studies re‐evaluating Wallace's scheme should not be considered updates as such because they have not followed Wallace's reasoning, and all computer‐based analyses, including this one, are subject to the vagaries of the particular methods used.

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