Mosunetuzumab is a T-cell reliant bispecific antibody that binds to CD3 and CD20 to trigger T-cell mediated B-cell death.
However, cytokine release syndrome, which has the potential to limit dose and efficacy, can result from powerful immune stimulation with T-cell focused treatments.
We created a novel mechanistic model of immune and antitumor responses to the T-cell bispecifics (mosunetuzumab and blinatumomab), taking into account the dynamics of B- and T-lymphocytes in circulation, lymphoid tissues, and tumors, in order to better understand the mechanisms underlying safety and efficacy as well as to explore safety mitigation strategies.
Using mosunetuzumab nonclinical and blinatumomab clinical data, the model was created and validated. The initial step-fractionated dose was projected to minimize systemic T-cell activation and cytokine release without impairing tumour response.
Simulations described the mechanisms underlying the observed cell and cytokine (IL6) dynamics. The Phase I clinical study for mosunetuzumab was changed to a step-fractionated treatment schedule as a result of these findings, allowing for the safer administration of greater dosages.
Learn more about cytokine brainly.com/question/14161482
#SPJ4
Answer:
Mycelium is part of the fungi kingdom and is the network of threads, called hyphae, from which mushrooms grow. Not all mycelia fruit mushrooms, depending on the environmental conditions, but all mushrooms come from mycelia.
Explanation:
Answer:
Vmax/ total enzyme concentration (Et)
Explanation:
According to the kinetics of Enzyme catalyzed reaction, the enzyme binds substrate and form the enzyme-substrate complex. The rate constant for this complex formation is K₁.
The enzyme complex later dissociates into the product and the enzyme itself ans the rate constant for this reaction is k₂. An enzyme-catalyzed reaction has the maximum velocity called Vmax.
The k₂ is also known as the turnover number which represents how many substrate molecules are converted into the products.
The mathematical expression for this reaction is the:
Vmax/ total enzyme concentration
Thus, Vmax/ total enzyme concentration (Et) is correct.
Cinnamon apple. that's my personal fave.
<em>Answer:</em>
<em>Which phrase describes one characteristic of radioactive elements isotope</em>
