A spatial relationship is related to place. Hence, the best answer is A, since the word "under" refers to going below an object, and this is related to space. The use of "by" in B is related to time. Choice C does not have a preposition related to space, and neither does choice D.
Answer: Asthma
Explanation: the lungs losing air and failing to bring in Oxygen
This would be the first choice.
I hope i helped!
