Answer by JKismyhusbandbae: Repeated drug use may lead to drug tolerance which occurs when a user requires larger amounts of the drug to achieve the desired effect.
I believe that it relates to or involves free oxygen, if it is used in exercise- aerobic practices help improve the the efficiency of the body's cardiovascular system with absorbing and transporting oxygen.
Hope this helps
The answer is evolutionary!
I hope I was able to help. :)
I think it might be Atari or Nintendo nes. or maybe Mario or pong. honestly I am not 100% sure what they mean by "mainstream appeal"
