One negative impact would be people or citizens of the Panama would dislike that Indigenous people can come over into the Panama and the trading would extend until free trade without quotas or tariffs.
Jamestown offered anchorage and a good defensive position. Warm climate and fertile soil allowed large plantations to prosper.
Plymouth provided good anchorage and an excellent harbor. Cold climate and thin, rocky soil limited farm size. New Englanders turned to lumbering, shipbuilding, fishing and trade.
The answers that apply are A, B, and D.
