Original formula Listerine is 26.9% alcohol, making it approximately 54 proof. According to the US, one "standard" drink contains roughly 14 grams of "pure" alcohol—so one standard drink of Listerine is 2.2 fl. oz. (so there are about 23 standard drinks in one 1.5 L bottle of Listerine).
Here, given-
homozygous alleles 'a' have a frequency of 0.3.
Also the alleles are in equilibrium in a Hardy-Weinberg population. The frequency of individuals that are homozygous for this allele are= 0.49.
The Hardy-Weinberg equilibrium can be defined as the principle which states that the variation in the genetic makeup of a population remains constant and unchanged till there are no external interferences, influencing the population.
Calculation-

Then to find the frequency of the individuals homozygous for this allele the following formula needs to be used-


Thus, the individuals homozygous for the allele can be calculated by 
Learn more about the Hardy-Weinberg equilibrium here-
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I have no idea but i think because long term activation is long term rather than nuclear. this is wrong