It is the excessive use of credit. The shares trading system crash of 1929 touched off a chain of occasions that dove the United States into its longest, most profound monetary emergency in its history. It is awfully shortsighted to see money markets crash as the single reason for the Great Depression. A solid economy can recuperate from such a compression.
To travel from coast to coast it would take 10 days.
Assuming that you are talking about the disagreements between Thomas Jefferson and Alexander Hamilton
The disagreements between those two cabinet members led to the establishment of the firs U.S Political Parties.
Thomas Jefferson formed the Democrat-Republican Party while Alexander Hamilton formed the Federalist Party