Answer:
Exosomes as Therapeutic Target
Given the fact that elevated exosome levels are often correlated with greater severity of different types of cancer, reducing circulating exosomes to normal levels is one of therapeutic strategies to increase treatment efficacy. There are different approaches to modulate exosome production: 1) Inhibition of exosome formation: inhibit crucial proteins involved in exosome formation pathway; 2) Inhibition of exosome release: inhibit important regulators of exosome release process, increased intracellular Ca2+, change cellular microenvironmental pH; 3) Inhibition of exosome uptake: add proteinase for surface proteins on exosomes may serve as receptors for uptake pathways. In addition to control exosomes production, removal of exosomes from the entire circulatory system might be a novel strategy for cancer treatment.
Exosomes could also be used as cancer immunotherapy becasue tumor-derived exosomes carry antigens that is a great source of specific stimulus for the immune response against tumors. Both tumor-derived and dendritic cell-derived exosomes have showed capability to stimulate tumor antigen-specific responses in experimental animal models and human clinical trials.
Exosomes as Targeted Drug Delivery Vehicles
Exosomes became one of the most common methods applied in drug delivery system because of several advantages they have. Firstly, exosomes normally have a small size 40-100 nm, which is more homogenous compared to other microvesicles. This will lead them to evade rapid clearance by the mononuclear phagocyte and enhances passage through fenestrations in the vessel wall. Secondly, due to their endogenous origin, they are less toxic for and better tolerated by the immune system. It facilitates them to avoid causing side effects that normally occur with synthetic nanoparticles. Additionally, the specific ligand or protein expressed on the exosome surface increases efficiency of cargo into the cytosol of the target cell, and therefore fewer off-target effects. Exosomes are generally found most useful as a drug delivery medium in cancer therapy, anti-inflammation and gene interference therapy such as transferring of miRNA.
There are different kinds of cargos encapsulated by exosomes, especially like siRNA or miRNA. The delivery of RNA is attracting because they are rapid degradation in cell circulation and have the limitation in passing through the membrane and in cellular uptake. Chemotherapeutics loaded into exosomes is also used for cancer therapy such as doxorubicin. In principle, there are four key components to achieve correct functionality and efficacy during exosomes drug delivery:1) Choosing the donor cell type to produce drug-carrying exosomes; 2) Using correspond methods to encapsulate the exosomes cargo; 3) Enhancing the specificity of cargo delivery by targeting peptides on the surface of the exosomes; 4) Administrating exosomes to target the area of disease.
Explanation:
https://www.creative-biostructure.com/exosome-applications-652.htm
Answer:
Bacteroides plebeius which is present in the gut humans have the same genes to marine bacterium Zobellia galactanivorans.
Explanation:
many researchers findout that bacteroides plebeius acquired functional porphyranase and agarase genes from a marine bacterium called Zobellia galactanivorans. Zobellia galactanivorans is a marine bacterium which has the ability to digest complex polysaccharides such as agarose and porphyran. so due to similar genes, Bacteroides plebeius also digest polysaccharides such as agarose and porphyran present in sea weed.
Answer:
Nitrogen
Explanation:
nitrogen, which accounts for about 78% of the mass of dry
thoughtco.com
Lipid bilayer model was proposed for its structure but it was modified and new structure is according to fluid mosaic model. Plasma membrane is selectively permible as it selects small molecules like lipid etc (composition is also of lipid and as solubility principle like dissolve like) so large and charged molecules like plasma and ion can't pass through it. Lipid are in form of layer so at the chain when ever other phosphate group attach the place conjugate molecule (phospholipid ) formed
Let’s assume a wire-hair terrier is a true breed for wire hair with alleles (BB) and a smooth-hair terrier is true breed for smooth hair (bb). Allele B is dominant over its allele b. When these two terrier mated and produce offspring wire-hair terrier and smooth-hair terrier in the ratio 3:1.
Based on this result it can be inferred that –
a. The pattern of inheritance is monohybrid cross.
b.Genotype of wire-hair terrier (1BB and 2 Bb) and genotype of smooth-hair terrier is (bb)
c. Phenotype ratio will be 3:1 and genotypic ratio will be 1:2:1.
