William Penn came in possession of land in the new world because the King Charles II owed William Penn's father a sum of money who was an Admiral. For the repayment of the debt, the William Penn demanded some land.
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Trade between native American communities and Europeans began in the 16th century up to the late 19th century. It was important for the creation and maintenance of trade relations with the new colonists. Besides, the native Americans helped the new settlers by teaching them skills needed for cultivating the land as well as hunting. Furthermore, the native cultures benefited from the colonists knowledge of the creation of wealth by means of capital (land), labor and entrepreneurship. In addition, they shared cultural knowledge and learnt the customs from both sides.
Hippocrates - Medicine
Euclid - Mathematics