Homologous recombination occurs in a heterozygote in which alleles D and d differ by a single base pair. The D allele has a G (a
GC base pair) at one position, whereas the d allele has a C (a CG base pair) at the same position. If branch migration causes heteroduplex formation across this position, what is the expected outcome
Mismatch DNA repair mechanism recognizes the abnormal base pairing (G-G base pair) and may correct it by converting the D allele to d
Explanation:
The DNA mismatch repair can be defined as a specialized mechanism that recognizes and repairs errors in the nuclotide sequence (such as, for example, bases erroneously incorporated) during DNA replication and recombination. The DNA mismatch repair is a system that also acts to repair the DNA after damage. It has been shown that the DNA mismatch repair mechanism leads to the generation of a DNA molecule with one chain that has the nucleotide sequence arising from DNA repair and one parental chain. In this case, it is expected that the DNA mismatch repair mechanism will identify the abnormal G-G base pairing and then this system may change the D allele to a d allele by introducing a C base instead of a G base in the DNA strand.
In meiosis, the chromosome pairs do the crossing over where there is an exchange of genetic material between them and because of it the
chromatids held together by the centromere are no longer the same.
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Niclosamide is an anti-helminth drug. It works by inhibiting ATP generation in the mitochondria. ATP which is a major source of energy for cellular organisms is deficient thereby hindering or stopping metabolic processes and then death. Helminths in which Niclosamide is effective against include Pin worm, Round wo,Beef tapeworm( Taenia saginata) etc. The drug is taken orally.
