Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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Delusions is a idiosyncratic belief or impression that is firmly maintained stating that they make false impressions on people
Some symptoms are irritable angry or a low mood also hallucinations
Dear Sarah.
Firstly, I am very happy to know that you have decided to start a study schedule for your literature course in Colonial Latin America, I believe that you will gain great knowledge and that this will be very important for your academic career.
Because of the importance of this study, I decided to analyze your study methods and I fear that they are not efficient and that you will lose time and do not absorb the concepts really necessary for you.
Your study method is based on memorizing concepts and quotes and I believe that you should not rely on it to study, as our memory is relative and often does not last as long as necessary. So I decided to give you advice that I used during my study and that were extremely efficient.
My first advice is that you divide all the material that you have to study in small modules and establish an expert for the study of each one. Don't forget to put a rest time so that you don't get overwhelmed and start taking your readings automatically.
My second advice is that when you study each module, write summaries with the main parts and make mind maps that will be extremely necessary to make revisions.
My last and most important advice is that you make constant reviews and try to conceptualize and reason during this process, this will prevent you from memorizing, but introducing the concepts in your mind in order to understand them and not record them.
I am grateful that you will be successful if you follow these steps and I expect answers from you telling me the results.
Affectionately,
Caroline.
Mitochondria produce ATP, energy that is vital in aerobic cells. Therefore, I believe this is why they can be considered as power plants.
